劉斌 教授
Prof. Bin Liu
Important experience / 重要經歷
Provost’s Chair Professor, National University of Singapore
新加坡國立大學教務長講座教授
Head of the Department of Chemical and Biomolecular Engineering, National University of Singapore
新加坡國立大學化學及生物分子工程學系主任
Royal Society of Chemistry’s Centenary Prize (2021)
英國皇家化學會百年獎 (2021)
Kabiller Young Investigator’s Award in Nanoscience and Nanomedicine(2021)
Kabiller 年輕研究員獎 (奈米科學及奈米醫學) (2021)
American Chemical Society Nano Lectureship Award (2019)
美國化學學會奈米講師獎 (2019)
President’s Technology Award (2016)
總統科技獎 (2016)
Materials in Society Lectureship (2015)
Materials Today期刊Materials in Society系列講師 (2015)
Research Areas / 研究範疇
Luminescent materials (conjugated polymers and oligomers)
Organic nanomaterials
Sensing and Imaging
Solar Cells
發光材料 (共軛聚合物及寡聚物)
有機奈米材料
感測及成像
太陽能電池
Introduction / 簡介
Dr. Bin Liu is currently Professor and Senior Vice Provost of the National University of Singapore (NUS). She is also a Fellow of the US National Academy of Engineering, Singapore National Academy of Sciences, the Academy of Engineering Singapore, Asia-Pacific Academy of Materials, and the Royal Society of Chemistry. She received B.S. degree from Nanjing University and Ph.D. degree from NUS, before her postdoctoral training at the University of California, Santa Barbara. She joined NUS in late 2005 and was promoted to Dean’s Chair Professor in 2014 and Provost’s Chair Professor in 2017.
Liu’s research is focused on organic nanomaterials for energy and biomedical applications. She is among the World’s Most Influential Minds and Top 1% Highly Cited Researchers in Materials Science and Chemistry 2014-2021. Liu has received many prestigious awards, and the recent ones include ACS Nano Lectureship Award 2019, the RSC Centenary Prize and Medal 2021, and Kabiller Young Investigator Award 2021. Liu is passionate about nurturing the next generation research leaders and encouraging more women to pursue careers in science, engineering, and nanotechnology.
劉斌博士是新加坡國立大學教務長講座教授，她亦是美國國家工程院院士、新加坡國家科學院院士、新加坡國家工程院院士、亞太材料科學院院士及英國皇家化學會會士。她畢業於南京大學，並在新加坡國立大學取得博士學位。及後她於加州大學聖塔芭芭拉分校進行博士後研究。她在2005年加入新加皮國立大學，及後於2014年成為院長講座教授；2017成為教務長講座教授。
劉博士的研究聚焦在有機奈米材料在能源及生物醫學之應用。她在2014-2021年期間，被選為世界最具影響力的科學頭腦及材料科學及化學首1%被高度引用之研究者。劉博士獲得很多的殊榮，近年獲得的包括：美國化學學會奈米講師獎 (2019)、英國皇家化學會百年獎 (2021)、Kabiller 年輕研究員獎 (2021)。劉博士亦致力於培育下一代研究者及鼓勵更多的女性投入科學、工程及奈米科技領域之發展。
Abstract / 摘要
Title: Aggregation-Induced Emission: Materials and Biomedical Applications
The recent years have witnessed the fast grow of fluorogens with aggregation-induced emission characteristics (AIEgens) in biomedical research. The weak emission of AIEgens as molecular species and their bright luminescence as nanoscopic aggregates distinguish them from conventional organic luminophores and inorganic nanoparticles, making them wonderful candidates for many high-tech applications. In this talk, we summarize our recent AIE work in the development of new fluorescent bioprobes for biosensing and imaging. The simple design and fluorescence turn-on feature of the molecular AIE bioprobes offer direct visualization of specific analytes and biological processes in aqueous media with higher sensitivity and better accuracy than traditional fluorescence turn-off probes. The AIE dot probes with different formulations and surface functionalities show advanced features over quantum dots and small molecule dyes in noninvasive cancer cell detection, long term cell tracing, and vascular imaging. In addition, our recent discovery that AIEgens with high brightness and efficient reactive oxygen species generation in aggregate state further expanded their applications to image-guided cancer surgery and therapy. Recently, we combined accurate prediction of material performance via first-principle calculations and Bayesian optimization-based active learning to realize a self-improving discovery system for high-performance photosensitizers, which can significantly accelerate the materials innovation for biomedical research.
題目：聚集誘導發光：材料及生物醫學應用
近年具聚集誘導發光特性的螢光素(AIEgens)在生物醫學研究上發展迅速。聚集誘導發光特性螢光素作為具弱發射性的分子物種及作為具亮發光性的奈米級聚集體，讓它們可以由一般的有機發光團及非有機奈米粒子中分辨出來，使它們適合使用在許多高科技應用中。
在這次講座中，劉博士會講述她及其團隊近期的聚集誘導發光的研究，開發新的螢光生物探針用於在生物感測及成像。這種的生物探計比傳統的有更高的敏銳度及更為準確，並在非入侵性癌細胞偵測、長期的細胞追蹤及血管成像有更好效果。在此之外，更發現一種具有高亮度及高效活性氧的聚集誘導發光特性螢光素可以擴充其應用範疇至癌症圖像引導手術及治療。
最近，劉博士及其團隊通過第一原理計算及貝葉斯優化主動學習，並結合對材料特質的準確預測，實現在高效能光敏劑中的可自我提升的發現系統，可以明顯地加速生物醫學研究上的材料革新。
More about the speaker / 更多關於講者
https://www.nus.edu.sg/about/management/liu-bin
More information / 更多資訊
https://cde.nus.edu.sg/chbe/staff/cheliub/