Photo credit: David Sella
蔡立慧 教授
Prof. Li-Huei Tsai
Important experience / 重要經歷
Director, The Picower Institute for Learning and Memory, MIT
麻省理工學院皮考爾學習與記憶研究所所長
Picower Professor of Neuroscience, Department of Brain and Cognitive Sciences
腦與認知科學系皮考爾神經科學教授
Senior Associate Member, Broad Institute
博德研究所資深附屬會員
Academician, Academia Sinica
台灣中央研究院院士
Member of the National Academy of Medicine
美國國家醫學院院士
Fellow, American Association for the Advancement of Science (AAAS)
美國科學促進會會士
Fellow, National Academy of Inventors
美國國家發明家學院會士
Member, American Academy of Arts and Sciences
美國藝術與科學學院院士
Research Areas / 研究範疇
Alzheimer’s dementia
阿茲海默症導致的失智症
Down syndrome
唐氏症
Single Cell Transcriptomics and Epigenomics
單細胞轉錄組學與表觀遺傳學
iPSCs
誘導型多功能幹細胞
Brain Rhythms
大腦節律
Neuroimmune interactions
神經-免疫交互作用
Myelination
髓鞘化
ApoE
E型載脂肪蛋白基因
lipid metabolism
脂質代謝
Neuronal DNA damage
神經元 DNA 損傷
Introduction / 簡介
Professor Li-Huei Tsai is the Director of the Picower Institute for Learning and Memory at the Massachusetts Institute of Technology, and the Picower Professor of Neuroscience at the Department of Brain and Cognitive Sciences. Tsai is interested in elucidating the pathogenic mechanisms underlying neurological disorders that impact learning and memory. She uses multi-omic approach to decipher the pathophysiology of Alzheimer’s dementia (AD). Her team pioneered the use of patient-derived induced pluripotent stem cells (iPSCs) to produce various brain cell types and a novel 3D brain tissue model (miBrain) inclusive of a biomimetic BBB, myelinated neurons, and immune components to model AD pathology. She also pioneered the use of non-invasive sensory stimulation to treat AD. Tsai is a Fellow of the American Association for the Advancement of Science, a Fellow of the National Academy of Inventors, a Member of the National Academy of Medicine, an Academician of the Academia Sinica in Taiwan, and a Member of the American Academy of Arts and Sciences. She is a recipient of the Mika Salpeter Lifetime Achievement Award, and the 2018 Hans Wigzell Research Foundation Science Prize for her research on Alzheimer’s disease. In 2022 she was named a Visiting Professor of the Vallee Foundation.
蔡立慧教授現任麻省理工學院皮考爾學習與記憶研究所所長，同時也是腦與認知科學系皮考爾神經科學教授。蔡教授對於釐清影響學習與記憶之神經疾病背後的發病機制深感興趣。她使用單一細胞多體學方法來解析阿茲海默症的病理生理學。她的團隊率先利用患者來源的誘導性多功能幹細胞培養出各式型態的腦細胞，並開發出用於新穎、用於阿茲海默症的3D腦組織模型，其中包含仿生血腦屏障、髓鞘化神經原，和免疫成份。同時她也使用非侵入性的感官刺激來治療阿茲海默症。蔡教授是美國科學促進會會士、美國發明家學院院士、美國國家醫學院院士、台灣中研院院士，以及美國藝術與科學學院院士。她榮獲Mika Salpeter終身成就獎，並憑藉其在阿茲海默症領域的研究，獲得2018年Hans Wigzell研究基金會科學獎。在2022年，他獲聘為Vallee 基金會的客座教授。
(由蔡立慧教授2025年6月提供)
More about the speaker / 更多關於講者
https://tsailaboratory.mit.edu/li-huei-tsai/